Van de Ven Double Halts The Toffees' Unbeaten Streak at Brand New Stadium
Micky van de Ven became the initial backline player to score two goals in a English top-flight match for Spurs since Jan Vertonghen in spring 2013.
Match summary
Micky Van de Ven nods home two times in first half
The home side's Jake O'Brien has equalizer ruled after VAR review
Senegalese midfielder nets final goal in dying moments
The defeat is the Merseyside club's initial at their new ground
Micky van de Ven found the net on two occasions as Spurs extended their unbeaten run on the road in the top division and delivered the Toffees their initial loss at their new home.
The Toffees were unbeaten in their five previous fixtures at their recently opened stadium at the dockside location, having departed Goodison Park behind after more than a century at the conclusion of the previous campaign.
But Spurs captain the Dutchman pounced twice from set-pieces in the first half to place their impressive record at risk, and they were failed to turn it around before Pape Matar Sarr - set up by ex-Everton forward the Brazilian - headed home a final goal to seal the victory.
Jake O'Brien believed he had levelled the tally a short while after the defender's opener, directing a powerful header past the Spurs keeper from an Everton corner.
The Portuguese striker, meanwhile, failed to convert a number of opportunities, while the Italian goalkeeper made a series of fine saves to ensure Tottenham went five matches on the road unbeaten in the Premier League.
But the video assistant referee intervened, advising Craig Pawson to check the score on the screen and the official ruled that Jack Grealish and the attacker were in an illegal position and had impeded with the Tottenham goalkeeper.
This victory moves Thomas Frank's side into third place in the Premier League, five points off north London rivals and table-toppers the Gunners.
The Merseyside club remain in 14th position and sit six points ahead of the drop zone.
Tottenham analysis: Van de Ven excels in duties at both ends of the field
After a uninspiring weekday display in the European competition against Monaco, where they managed a only two shots on goal, the manager opted for Randal Kolo Muani up front instead of former Toffees player Richarlison.
The new arrival was unable to influence the game before being substituted for the substitute after an hour on the field, but it emerged he wasn't needed in the final outcome.
Centre-back Van de Ven converted into an offensive threat to be reckoned with.
Tottenham's first goal came from a well-worked set-piece play, with Rodrigo Bentancur heading the ball toward the six-yard box for an unmarked the defender to head home.
And the captain - stepping up as captain in the Argentine's absence - notched his next goal in added time as he rose above the England keeper to head home.
The Dutchman was just as outstanding in defensive duties, partnering effectively with his defensive colleague as the pair handled superbly with the 34 crosses thrown their way by the opposition.
Everton analysis: Toffees lacking striker's instinct
Everton's new home had been a fortress, but it seems the novelty may have worn off slightly and supporters flocked to the exits after the midfielder's final goal for Spurs.
The break in Everton's unbeaten home run won't be a major worry for David Moyes, but their attacking woes are.
Beto and Thierno Barry - the Toffees' two established strikers - had scored just a single goal combined before Sunday's outing.
And they were failed to contribute to that miserable record on a damp and dreary evening on in Liverpool.
Beto's performance was epitomized when he chose to overhead kick a clear chance from near the goal, despite having space and time to readjust for a more conventional shot that would have challenged Vicario.
The substitute, too, failed to influence the game after coming on for Beto in the second half.
It was not for a lack of chance. Most of the home side's attacks came through the winger and the forward, who relentlessly delivered dangerous crosses into the Tottenham penalty area.
Upcoming fixtures for these two sides?
Everton: The team travel to the Stadium of Light in the Premier League on Monday, 3 November at 20:00 GMT.
Tottenham: Spurs travel to St James' Park on Wednesday, 29 October for their next round Carabao Cup tie against the Magpies.